But even by python standards, this one was colossal.
The picture with the Facebook post tells it all.
Four researchers posted a picture of themselves holding the huge reptile, which was posted on the reserve's Facebook page. Some pythons grow as much as 20 feet long.
In December, a huge 18-foot-long python weighing 150 pounds was caught roaming in the Everglades.
Still, this latest find is impressive.
The preserve said the new approach includes using male pythons that have been equipped with transmitters that help lead researchers to breeding females.
State wildlife officials estimate there are as many as 100,000 pythons living in the vast swamps outside Miami.
All of the python work at big Cyprus is repeatedly focused on controlling invasive species which pose threats to native wildlife.
Hunter John Hammond caught the snake, which was subsequently euthanized, as part of the Python Elimination Program.
Python hunters are said to have caught more than 1,850 of the snakes in the area after they started to wreak havoc on Florida's ecosystem. Everglades National Park scientists trained a beagle puppy named Python Pete to sniff out the snakes, but had to abandon the venture when Pete wilted in the heat of the Florida summer. Others escaped from a breeding facility wrecked by Hurricane Andrew in 1992.