"This case is about the widening corruption of elite college admissions through the steady application of wealth combined with fraud", Lelling said.
"For every student admitted through fraud", Lelling said, "an honest, genuinely talented student was rejected".
Dressed in a blue fleece paired with black trousers, Huffman appeared downcast as she waited by an elevator in the building with what appeared to be two federal agents.
Federal Bureau of Investigation spokeswoman Laura Eimiller said Loughlin is in custody Wednesday morning in Los Angeles.
All University of Southern California applicants who are connected to the alleged admissions cheating scheme will be denied admission, university spokesman Gary Polakovic said Wednesday.
The report also claims that Huffman "later made arrangements to pursue the scheme for a second time" to help her youngest daughter through the admission process, but ultimately chose "not to do" so. Huffman allegedly paid $15,000 for her oldest daughter and began the process for her second child but ultimately abandoned the plan because she was anxious a fixed score would "set off alarm bells".
Huffman is best known for her role as Lynette Scavo on "Desperate Housewives".
Felicity Huffman, Lori Loughlin Among Dozens Charged In Nationwide College Admissions Scheme
Full House star Lori Loughlin and her designer husband Mossimo Giannulli meanwhile are accused paid $500,000 to have their two daughters labelled as recruits to the USC crew rowing team, even though neither participated in the sport. Their daughters, Isabella Rose Giannulli, 20, and Olivia Jade Giannulli, 19, are both enrolled at University of Southern California.
Some 33 parents, including Huffman and Loughlin, were charged, as well as 13 coaches and associates of Singer's business.
Prosecutors have said colleges are not targets of their criminal case.
Yale University and USC said in separate statements they were cooperating with investigators.
There were dual avenues for carrying out the scheme, Lelling explained.
Singer also collected money to pay other people to take the SATs and ACTs for the children of his clients. Singer allegedly helped parents "take staged photographs of their children engaged in particular sports", and in other instances used stock photos by "sometimes Photoshopping the face of the child on the athlete, and submitting it". He pled guilty in federal court on Tuesday. Academic officials, including the former women's soccer coach at Yale University are also facing charges.
Wake Forest said it had placed head volleyball coach Bill Ferguson on administrative leave after he was among the coaches accused of accepting bribes.