The four-legged lunar lander represents the country's first attempt to land on the Moon, but it also happens to be the first privately-funded lunar lander. Eastern Time from Cape Canaveral Space Center in Florida aboard a SpaceX Falcon 9 rocket.
The launch of Beresheet, which means "Genesis" or "In the beginning" in Hebrew, represents a significant milestone for both Israel and the private sector.
It will take almost two months for the unmanned robotic spacecraft, called Beresheet - Hebrew for Genesis or "in the beginning", to reach the moon, with an anticipated touchdown on April 11. The probe has a scientific device for the measurement of the magnetic field of the moon; the main objective of the Mission is the landing on the moon is as such.
"We thought it's about time for a change, and we want to get little Israel all the way to the moon", said Yonatan Winetraub, co-founder of Israel's SpaceIL, a nonprofit organization behind the effort.
Beresheet would mark the first non-government lunar landing.
SpaceIL pressed on, signing with Elon Musk's SpaceX to launch its craft on board a Falcon 9 rocket.
The mission: The lander launched alongside the primary payload, the Indonesian telecommunications satellite Nusantara Satu, which was deployed without issue.
The landing sequence is set to take around 15 minutes and will monitored by a joint group of scientists and engineers from the Israel Space Agency (ISA), the Weizmann Institute of Science, and NASA.
Stored inside is a totem to the nation: a time capsule in the form of three disks containing Israeli artefacts such as its Proclamation of Independence, national songs and drawings by Israeli children. The company continued to develop the lander that's now en route to the moon.
Formed in 2011, SpaceIL were the first team to announce a signed launch contract and in January 2017 were named as one of the five finalists in the competition. President Reuven Rivlin hosted a pajama party with schoolchildren, hoping the lunar mission will galvanize science education in Israel the way the Apollo space program did in the USA decades earlier. SpaceIL officials say that the data collected will help scientists learn more about the creation and evolution of the moon.