By Tuesday morning we could be in the single digits above zero in Denver.
Blizzard conditions are predicted across parts of the western Ohio Valley and snow is expected Tuesday through Wednesday from the Great Lakes region into New England, the weather service said. Some of the higher terrain in parts of Tennessee, Alabama and Georgia will see feels like temperatures approach zero with below zero reading in the North Carolina mountains. That's the day Chicago is forecast to see its lowest daily high temperature ever - minus 12, beating the record of minus 11 set in 1994.
Snowplow drivers had trouble keeping up with the snow in Wisconsin and Minnesota, where up to 14 inches (35.5 centimeters) is expected.
As an arctic cold plunges into the Midwest, highs in some cities will be well below zero, and wind chills could be more than minus 50 degrees.
According to Accuweather, areas along the I-80 and I-94 corridors are expecting snow and slippery conditions beginning on Sunday and continuing through early next week.
Cold weather advisories are in effect across a broad swath of the central US, from North Dakota to Missouri and spanning into Ohio.
A preview of the expected storm hit on Friday morning, prompting multiple school closures in the Midwest and temperatures of -27 degrees Celsius in Duluth, Minnesota and -20 degrees Celsius in Chicago, Illinois, the largest city in the Midwest.
Heavy snow and gusting winds have also created blizzard-like conditions in Minnesota, Wisconsin, northern IL and other Midwestern states where officials have also closed schools, courthouses and businesses.
In Wisconsin, plow drivers were having a hard time keeping up with the snow in Sheboygan.
Wisconsin Gov. Tony Evers declared a state of emergency and activated the National Guard.
Courthouses and most offices were closed in Milwaukee, Waukesha, Columbia and Washington counties, while more than three dozen flights were canceled early Monday at Mitchell International Airport in Milwaukee County.
In eastern North Dakota, officials have issued travel alerts because of blowing snow.