The three-time Grand Slam champion announced during an emotional pre-Australian Open press conference that he is planning to retire at Wimbledon. It's unclear exactly when he'll be walking away from the sport, but it will likely be sometime in 2019.
"It is a similar feel to drawing Kevin Anderson in the first round past year, but I was in a good place and managed to come through in the fifth set. I tried pretty much everything that I could to get it right - that hasn't worked".
While two months' pregnant, Williams claimed a record seventh Australian Open title in the professional era in 2017 but missed out on her title defense while on maternity leave.
"I think his injury of the hip is something certainly far worse than mine, my injury because it's obviously something that he's been carrying for a while, for a couple of years. But I'm also not certain I'm able to do that".
"I don't think it is impossible, but it will be very hard", Dr John O'Donnell told BBC Radio.
While Murray may be participating his last Australian Open, a win the tournament has higher stakes for some of the other player.
The two-time Grand Slam mixed doubles champion was accused of attacking one-time friend Randall Kaplan. "You've just not got to have many expectations". "We will all be cheering for you these next few months".
And question marks remain over the fitness of world No. 2 Rafael Nadal who pulled out of his Brisbane warm-up but arrived in Melbourne professing he was "fully fit" and promising to unleash a remodeled serve. "His achievements - there are no greater goals you can achieve in our sport". 'Realistically I don't think there is anywhere else to go to preserve his hip and get it better so he can continue to play.
That Andy Murray is the first of the long-time leading four in men's tennis to signal the end of his career is something Nadal has to keep in perspective.
"But being honest, when somebody like him, that he achieved nearly everything in his tennis career, is suffering like he's done for such a long time already, and you feel that you are not competitive for the thing that really makes you wake up every morning and go on court with the passion to practice, to improve, and with a goal, then it's so hard, no?" I'm just taking it as a nice, fun challenge. As an athlete, that's probably the biggest obstacle and enemy that you can have: an injury. Goodluck at the Australian Open muzz, I'll be behind you. Your greatest impact on the world may be yet to come. "They love their tennis, as well".
And he is expected to breeze through the first round in Melbourne against James Duckworth, an Aussie 26-year-old ranked 254th in the world.
"Hope he will make it through to Wimbledon and have the farewell he deserves", tweeted former tennis player Kim Clijsters.
"That's something that ATP is definitely, us as players, part of the council, are trying to change".
"Tennis is better with you", tweeted current world No. 6 Kevin Anderson.
"I guess everybody can understand where he comes from". That's sports sometimes. You can't help when your body says it's enough.