The show's hosts, Sandra Oh and Andy Samberg, mostly avoided politics in their opening comments.
The film also won the "Best Motion Picture - Drama" category.
Tears and astonishment marked the winners podium as Glenn Close for "The Wife" beat front-runner Lady Gaga as best drama actress, and "Green Book" triumphed over more high profile comedies "Vice" and "The Favourite". I think they wanted to enjoy it, it was an exceptional night for everybody, but they're used to being rock stars and doing rock star things and that was a very Hollywood industry night which I had a blast at.
"I see you, all these faces of change, and now so will everyone else", Oh told the crowd at the Beverly Hilton Hotel.
The Queen's Guard captivate tourists as they perform Bohemian Rhapsody in the courtyard outside Buckingham Palace in social media footage. I was also vaguely aware the director of said film was bad but had no other information as to why he was considered such or what he had done.
"Thank you to Satan for giving me inspiration on how to play this role", Bale said after winning for his performance in the political satire film Vice.
"The Kominsky Method" won Golden Globes for best comedy and best actor for its star Michael Douglas.
The news comes on the heels of a big night for Bohemian Rhapsody's cast and crew last Sunday at the Golden Globes. Indeed, Bohemian Rhapsody feels more like an obituary than a biography at some points, often dealing in half-truths rather than providing context to a man who was notoriously private.
Politics was a big topic as usual.
However, according to review-aggregation website Rotten Tomatoes, "Bohemian Rhapsody" is the worst-rated movie to win Best Picture since 1986, when the romantic epic "Out Of Africa" claimed the title. Some of the scenes of "Vice" take a satirical approach, making of Cheney a malevolent player on the US political stage.
The Assassination of Gianni Versace: American Crime Story picked up two awards, one for actor Darren Criss and one for the Best Television Limited Series or Motion Picture Made for Television category.