Federal law bars the sale of e-cigarettes to those under 18.
"We issue surgeon general advisories at times when there's a significant public health threat and when we need an all-hands-on-deck response to that threat", he said. "They don't realize the nicotine can interfere with their brain development, that the sweet flavors don't make the products any less unsafe", Ryan said.
Vaping has also reached all-time high proportions among American kids.
The latest federal figures show that 3.6 million teens use e-cigarettes, which works out to 1 in 5 high school students and 1 in 20 middle school students, the AP reported.
Separate survey results released December 17 showed twice as many high school students used e-cigarettes this year compared to last year.
The devices first came onto the U.S. market around 2007.
The government's top doctor is taking aim at the best-selling electronic cigarette brand in the U.S., urging swift action to prevent Juul and similar vaping brands from addicting millions of teenagers.
JUUL has said its goal is to help adult smokers by providing them with a "true alternative" to combustible cigarettes.
"But we can not let them ensnare younger Americans into a new addiction".
Vaping among United States 12th graders, those in their final year of high school, doubled in the past year alone. Vaping among middle school-age children also increased by almost 50 percent. "This is an unprecedented challenge".
Omaha high school students say they don't have to look far to see it, "we mostly see it in the bathrooms. lunchrooms, if a teacher is away we'll see it there", said Burke High School sophomore, Anna Anthony".
The survey also found a significant jump in the perceived availability of e-cigarettes.
"We included e-cigarettes and vaping devices in the policy because nicotine in any form is highly addictive", said Cerri Banks, dean of students at the college.
"Less harm does not mean harmless". "Nicotine exposure during adolescence can harm the developing brain which continues to develop until about age 25".
"In addition to nicotine, the aerosol that users inhale and exhale from e-cigarettes can potentially expose both themselves and bystanders to other harmful substances, including heavy metals, volatile organic compounds, and ultrafine particles that can be inhaled deeply into the lungs", said the advisory.
U.S. Surgeon General Jerome Adams, known as the "nation's doctor", said of particular concern is the availability of new products, including ones shaped like a USB flash drive.