A shrewd investment at the beginning of the season, Xherdan Shaqiri has proven to be well worth the £13m they paid for his services, with the Swiss global playing his way into Jurgen Klopp's starting XI.
Defender Joe Gomez, who has been a standout player at both right-back and centre-back this season, is out six weeks.
That has put more pressure on them domestically, with Liverpool fans even more emotionally invested in the dream of winning their first league title since 1990.
But Gomez, 21, was thankful that his injury was not as bad as it potentially could have been.
Defender Andy Robertson is back after shaking off a dead leg while Georginio Wijnaldum is available after missing the match against Burnley.
Midfielder Adam Lallana was including in Liverpool's squad in midweek but didn't make it off the bench.
With City travelling to Chelsea in the late afternoon kick off, nothing but a win against Bournemouth will suffice for Jurgen Klopp's side.
Now two points clear of Liverpool at the top of the Premier League, Pep Guardiola's side will be aiming to emulate last season's superb win at Stamford Bridge. In his absence, Joel Matip should retain his place alongside van Dijk, with Trent Alexander-Arnold being deployed on the right. The Swiss winger has been proficient for Liverpool so far this season and Jurgen Klopp will hope he delivers again.
Origi, 23, has waited on the sidelines too for most of the season behind Roberto Firmino and Daniel Sturridge in the striker department. The trio played well together in the second half on Wednesday night.