"Pulling back our limited U.S. military support, our weapons sales to our partners, and our protection of the Saudi and Emirati populations would be misguided on the eve of the promising initial negotiations", he added. "It's not who we should have as allies and not condemn that".
Outrage in Congress over the humanitarian crisis in Yemen has simmered for months.
The conflict between Saudi-led military coalition and Houthi rebels has killed thousands of people and pushed millions more Yemenis to the brink of starvation. Canada has said it will no longer sign arms deals with the country, though it has not walked back its existing arrangements.
The US Senate, angered by the murder of writer Jamal Khashoggi, voted 63-37 on Wednesday to take up a war powers resolution that would curtail the Trump administration's military backing for Saudi Arabia's bombing campaign in Yemen. Pompeo did not mention Khashoggi in his prepared remarks to senators.
"The butchering of a journalist in a consulate on foreign soil, directed by a strategic partner, should be a red line that can not be crossed without severe consequences for all involved", Graham and Menendez wrote.
Senators suggested that the White House is barring Haspel from briefing lawmakers on the audio recording provided by the Turks, but CIA Press Secretary Timothy Barrett said the "notion that anyone told Director Haspel not to attend today's briefing is false".
"There will be another opportunity next week to decide whether we proceed to it", Senate Foreign Relations Chairman Bob Corker, a Tennessee Republican, said on the floor. It drew a mix of Democrats and Republicans who have grown uneasy with US involvement in the Saudi-led campaign against the Houthis in a war that human rights advocates say is subjecting civilians to indiscriminate bombing and wreaking havoc on the country. "It tells me volumes about what really is going on here".
"We have 17 individuals that have been sanctioned already". It sets up a highly public legislative fight beginning next week over the USA role in the Yemen civil war and by extension, the US's strategic partnership with Saudi Arabia in the war. This is the kind of behavior we expect from Russian Federation and North Korea.
Senatorial frustration is understandable, given that the administration sent Pompeo and Mattis to cheerlead the administration's policy of status quo with Saudi Arabia, but not an intelligence official who could provide answers to questions not tailor-made to fit the policy, former CIA analyst Cindy Otis said.
Pompeo said based on all the intelligence he has seen, there is no direct evidence linking the crown prince to Khashoggi's death.
President Donald Trump has also noted that the Central Intelligence Agency assessment isn't a conclusion, but a high confidence report. He has said he would be willing to meet with Mohammed but now has no meeting scheduled.
Khashoggi's killing, however, has dramatically changed the narrative on Prince Mohammed and the world is slowly turning against him.
In a rare classified briefing ahead of the Senate vote, Secretary of State Mike Pompeo and Defense Secretary Jim Mattis addressed the senators, yet failed to sway the undecided votes necessary to halt the measure, which is against Trump's interests.
Trump has dismissed the CIA's assessment as inconclusive "feelings" - prompting backlash from the Republicans' most senior ranks.
"There is no direct reporting connecting the crown prince to the order to murder Jamal Khashoggi", Pompeo told reporters.
But lawmakers have yet to agree to what the response is. "The way the administration has handled the Saudi Arabia event is just not acceptable". The federal government will shut down if a new spending bill isn't approved by December 7. He vowed last week to remain a "steadfast partner" of Saudi Arabia and said it was not clear whether the prince knew about the plan to kill Khashoggi.
The procedural vote received more Republican support than had been expected after a similar resolution fell six votes short of passage earlier this year.
"All we would achieve from an American drawdown is a stronger Iran and a reinvigorated ISIS and al-Qaeda in the Arabian Peninsula", said Pompeo, using an acronym for the Islamic State.
Coons called Haspel's absence "very unusual".
Emerging from the briefing, Pompeo said the vote would be "poorly timed" as diplomatic efforts to end the conflict are underway.
"Senators, I know all too well the difficulty in reconciling human aspirations with war's grim reality".
Murphy added that he thinks the GOP is eager to get onto the resolution, as once it has been taken up, it can be amended by a simple majority.