"We've had good times and bad times", said Hamilton, speaking to reporters ahead of this weekend's season-ending Abu Dhabi Grand Prix. Vettel is third all-time with 52, and did not look like adding to that in a race controlled by his rival.
A point appeared possible in the closing stages but the Spaniard was unable to close the gap on 10th-placed Kevin Magnussen.
Earlier, Verstappen was fastest in the first practice by about half a second.
A one-stopper has usually been the winning strategy, with Valtteri Bottas triumphing a year ago after starting on ultrasofts and moving to supersofts.
And Alonso, who has finished in the points just once in the last eight races, is braced for a testing weekend.
Romain Grosjean qualified seventh for Haas with Charles Leclerc eighth in his last race for Sauber before taking Raikkonen's place at Ferrari.
Esteban Ocon - set to be a reserve driver for Mercedes next season - retired late on, while Stoffel Vandoorne and Sergey Sirotkin are also without seats for next year.
Max Verstappen was closing on Vettel as the second Red Bull of Daniel Ricciardo closed on the Dutchman.
Hamilton's 11th win of the campaign matches his tally from the 2014 season and sees him surpass the 3,000-point marker, becoming the first driver to achieve that feat.
As well as 11 pole positions in 21 races this year, he has secured 52 in the last 100 grands prix and says it was an emotional feeling stepping out of his Mercedes W09 for the final time.
He was clipped by the Swiss driver and rolled several times after the clash. Hulkenberg had passed Grosjean on the inside of the chicane but appeared to lose sight of the Haas vehicle on the exit, with the Frenchman stuck on the inside when contact was made.
The shaken German remained in the upside down vehicle as marshals doused flames at the rear, finally clambering out through the halo head protection device after the Renault was turned over. Hulkenberg was later released, with doctors confident he had escaped the collision unharmed.