Evacuations are now under way, with tens of thousands of people having already been forced to flee their homes, and hot and dry weather conditions are exacerbating the problem.
In Northern California, the Camp Fire advanced rapidly to the outskirts of the city of Chico early on Friday, forcing thousands to flee after it left the nearby town of Paradise in ruins, California fire officials said.
While no homes or businesses have been lost due to the fast-moving blaze, a number of RVs and outbuildings have been burned and a firefighter suffered a minor injury, authorities said.
USA media reports that schools have also been closed and evacuated due to the fire, and animals have been moved out of the LA Zoo in Griffith Park.
Near Oak Park, the town of Thousand Oaks - still reeling from a mass shooting on Wednesday night - has also been threatened by the encroaching blaze. Early Friday morning, CalFire said it had burned 10,000 acres, or about 15 square miles. "All residents, from Ventura County Line to the area of the Getty Villa and the Ventura (101) Freeway to the ocean, must evacuate as soon as possible".
It is claimed that her home, which is in the same area of the Woolsey fire, went up in flames on Friday. The Los Angeles County Fire Department tweeted that the fire is headed to the ocean, punctuating the message with the declaration: "Imminent threat!" Thousand Oaks is a 30-minute drive north of Malibu.
The fire prompted the closure of all schools in the Las Virgines Unified School District in Calabasas, as well as Viewpoint School, Montessori of Calabasas, Montessori of Calabasas Too and Muse School, the city of Calabasas announced this morning.
The flames are being driven by Southern California's notorious Santa Ana winds, which blow from the northeast toward the coast. The flames have jumped the 101!
An earlier report said that five people were fatally killed in the fire while they were in a van trying to outrun the fire.
Portions of Southern California remain under siege as two large brush fires are threatening numerous communities.
Firefighters are challenged by residents moving about evacuation areas and high traffic as they follow the fire front.