They boast some of the biggest hitters in the game's shortest format and the arrival of a host of T20 specialists will boos their confidence.
Rohit Sharma will lead the side in the absence of Virat Kohli, who has been rested for the series.
Where and how to watch the online live streaming of India vs West Indies? The Caribbeans enjoy a 5-2 head-to-head record against India in T20Is.
West Indies have endured a hard tour, losing both Tests inside three days and then going down 3-1 in the subsequent one-day series.
All-rounder Krunal Pandya and left-arm pacer Khaleel Ahmed received their maiden T20I cap on Sunday as they made their debut for India in the first T20I against West Indies at Eden Gardens, Kolkata.
Months earlier, the Windies had also overcome the Indians in Mumbai, in the semi-final of the T20 World Cup, and Brathwaite said he was hoping for similar results in the three-match series.
India's last win against West Indies came way back on March 23, 2014 in the World T20 in Bangladesh, and Sharma will have his task cut out in his quest to start well at his happy hunting ground. Moreover, the visitors have been bolstered by the return of Keiron Pollard, Darren Bravo, Andre Russel and Carlos Brathwaite.
Captaincy seems to bring out the best in Sharma who notched up 317 runs (average 105.66) in five innings in their title-winning campaign at the Asia Cup.
Pant is expected to fulfil the wicket-keeping responsibilities while Karthik could take on one of the positions in the outfield.
As per the latest ICC rankings, India, however, are way ahead of the Windies.
The match will begin at 7 pm.
For the clash at historic Eden Gardens, there will be no Chris Gayle - the most successful batsman ever in T20s - nor any Evin Lewis, who has already plundered two centuries in 17 matches. Krunal Pandya is the only all-rounder in team that has 3 pacers - Bhuvneshwar Kumar, Jasprit Bumrah and Khaleel Ahmed and two spinners in Kuldeep Yadav, and Yuzvendra Chahal.