The Google protest, billed as "Walkout for Real Change", is unfolding a week after a New York Times story detailed allegations of sexual misconduct against the creator of its Android software, Andy Rubin.
While speaking at a New York Times event on November 1, Google's chief executive Sundar Pichai said the company clearly did not live up to the expectations of employees when it came to dealing with sexual harassment.
Google employees were seen walking out in Singapore and across Europe, including in London, Dublin, Berlin and Zurich. Rubin has denied parts of the Times story.
He said: "Employees have raised constructive ideas for how we can improve our policies and our processes going forward".
"We want to assure you that we review every single complaint about sexual harassment or inappropriate conduct, we investigate and we take action", said Pichai.
"We don't want to feel that we're unequal or we're not respected anymore", Claire Stapleton, 33, Product Marketing Manager at Google's YouTube, was quoted as saying.
DeVaul's departure comes as Google grapples with reports that it gave some executives multimillion dollar payouts despite allegations of sexual harassment against them.
Twitter and Instagram accounts have sprung up this week posting pictures of and information about the protest, which is being observed at Google offices around the world. DeVaul had remained at the "X" lab after allegations of sexual misconduct surfaced about him a few years ago, but he resigned Tuesday without severance, Google said.
The email did not mention the reported incidents, but Mr Pichai did not dispute details of the New York Times story.
"I am deeply sorry for the past actions and the pain they have caused employees", Pichai wrote.
"We don't want to feel that we're unequal or we're not respected anymore", Claire Stapleton, a product marketing manager at YouTube who helped call for the walkout, told The NY Times. However, last week's damning report continues to create huge ripples within Google and is the latest in an increasing number of sexual misconduct reports that manifested out of the #MeToo movement. Most have not been told, ' added organisers.
Google says it supported the protest and admits in the past two years, 48 workers have been fired over sexual misconduct claims, but say none received payments.
Many Google employees were reluctant to speak to the press because they were advised not to. They occupy slightly more than one quarter of leadership roles globally, according to Google data from 2017.
Pichai has supported these demonstrations, according to BBC.