It said Mr Quang - the country's number two after the ruling Communist Party leader - died at a military hospital in Hanoi, but did not elaborate on his illness.
The state television and radio of Vietnam announced on Friday morning, 21 September 2018 that President Tran Dai Quang, one of the top three leaders of the country has passed away after a bout of serious illness.
A career security officer, Quang was elected president in April 2016.
According to a statement from the commission, President Quang was in critical condition and has received treatments from a medical team at home and overseas.
During Tran Dai Quang's tenure as President, he oversaw a crackdown on dissidents that rights groups described as a chokehold on free expression, with more than 40 people being jailed this year itself.
Quang had appeared thin and pale in public, and was unstable on his feet last week when he hosted a welcoming ceremony for Indonesian President Joko Widodo in Hanoi last week. Although his was a rather ceremonial role, he was one of the key men within the powerful Political Bureau of the Communist Party of Vietnam (Pcv).
His was among the four most important positions in Vietnam's power structure, which also includes general secretary of the party, prime minister and head of the National Assembly.
At an APEC meeting in Danang in November a year ago, he hosted a group of world leaders, including US President Donald Trump and China's Xi Jinping.
"Even after becoming president, he continued to give the tone, and to supervise the suppression of its department of origin, accuses Andrea Giorgetta, the representative in Asia of the global Federation of human rights (Fidh)".