One day after the women's singles final was marred by a confrontation between Serena Williams and chair umpire Carlos Ramos, Djokovic defeated Juan Martin del Potro, 6-3, 7-6 (4), 6-3 with a minimum of fuss to secure his third title in Flushing Meadows and his 14th Grand Slam singles crown.
With the win on Sunday, Djokovic has extended his head-to-head record against Del Potro to 15-4 as the Argentine was unable to upstage the Serb.
Djokovic had lost five previous finals at Flushing Meadows, but he was determined to make amends for his lack of trophies in NY as his defensive ability combined with his ruthless prowess saw him break in the fourth game, although Del Potro was not in the mood to give up so easily as he hit straight back.
Djokovic faced similar questions about whether he'd ever get back to another major final with his elbow woes, but after his triumph at Wimbledon in July, and with the more heralded - and older - Rafael Nadal and Roger Federer showing signs of slowing down, another reign of the Djoker looks very real in men's tennis.
He missed last year´s tournament with an elbow injury which sent his career into a mini-crisis.
He now trails Roger Federer's record of 20 by six and is just three behind Rafael Nadal for second all-time.
But off the back of a 24-shot rally, Djokovic broke again for 5-3 and he was within tantalising touching distance of his 14th Grand Slam title, just three months after he had left Roland Garros in despair after a shattering quarter-final exit.
The result also means that 50 of the last 55 majors have been won by the "Big Four" of Federer, Nadal, Djokovic and Andy Murray.
Brace yourself for a stunning men's singles final between Novak Djokovic and Juan Martin del Potro. It's awesome. I don't feel sad that I couldn't win Grand Slams because of them. He won 79% of his first serve points in the first.
The match's true turning point came in the eighth game of the second set, after Djokovic had lost three straight games and was trailing 3-4 on serve. "I'm glad that Novak is the champion".
But in that critical eight deuce game, the three break chances evaporated and Djokovic leveled for 4-4.
A focused Djokovic continued to apply pressure in the third set until Del Potro finally cracked on serve to fall behind 5-3, with the Serb closing out the match with a ferocious overhead victor. "He's my idol. Pete, I love you". And the way he dismantled the big-serving Argentine to win his third US Open was a throwback to the early part of this decade, when he was the impenetrable wall, who became the best returner in tennis.