The airline says about 10 passengers were ill and got medical attention "as a precaution".
According to the press secretary for New York City Mayor deBlasio, at least 19 people in total were sick with what is likely the flu.
The plane was quarantined at JFK airport as those on board were checked by health officials.
Twelve passengers on global flights that landed at Philadelphia worldwide Airport on Thursday are showing flu-like symptoms, airport officials said. The plane has since been parked in a staging area at the airport, as emergency response teams check passengers and investigate the cause of the illness.
Flight 203 from Dubai landed at 09:10 (13.10 GMT) with 521 passengers.
Vanilla Ice also said via Twitter that "there [were] over 100 people sick on the bottom floor, so happy I'm up top, it's a double-decker plane 380".
No other flights or airport operations were affected, Gerace added.
All passengers aboard the plane were allowed to leave by Wednesday afternoon, according to an Emirates spokeswoman, who said three passengers and seven crew members were being treated at a hospital.
Officials from the Centers for Disease Control and Prevention and the Port Authority police were reportedly responding to the incident. He pointed out that the flight stopped in Mecca, which is experiencing a flu outbreak.
American Airlines did not immediately return Business Insider's request for comment.