The Dow Jones Industrial Average sank 137.65 points, or 0.5 percent, to 25,986.92.
The S&P 500 and the Dow Jones Industrial Average dipped on Friday as jitters over ongoing trade talks between the United States and other major economies weighed, but gains in Apple and Amazon kept Nasdaq slightly higher.
President Donald Trump told the U.S. Congress he plans to sign a trade deal with Mexico in 90 days, which Canada could join "if it is willing", Trump's top trade official said on Friday.
"Canada trade talks", writes CNBC.
The Canadian dollar traded down at 76.62 cents US compared with an average of 77.04 cents USA on Thursday.
The S&P index recorded 12 new 52-week highs and one new low, while the Nasdaq recorded 53 new highs and 20 new lows.
The Russell 2000 picked up 15.08 points, or 0.9 percent.
Canada's main stock index slipped on Friday following a report that a North American Free Trade Agreement (NAFTA) deal with the United States might not be concluded by the end of the day.
The Nasdaq Composite Index closed at 8,109.54 points, up 21.17 points, or 0.26 percent.
The most active companies traded on the market are Aurora Cannabis Inc., falling 3.1 percent to 8.79 Canadian dollars on 19.9 million shares and Aphria Inc. down 1.78 per cent to 16.01 Canadian dollars on 17.8 million shares while Cronos Group Inc., tumbling 28.1 percent to 11.77 Canadian dollars on 14.7 million shares.
The FTSE 100 Index closed at 7,432.42 points, down 83.61 points, or 1.11 percent.
Advancing issues outnumbered decliners for a 1.16-to-1 ratio on the NYSE and a 1.41-to-1 ratio on the Nasdaq.
(AMZN.O) was up 0.8 percent, topping $2,000 for the second day in a row to renew its push to join Apple in the $1 trillion market cap club.